Which statement best describes volume of distribution (Vd) and its relevance in toxicokinetics?

• A. The actual physical volume of blood in the circulatory system.
• B. The rate at which a chemical is eliminated by the kidneys.
• C. The theoretical volume relating the amount of drug in the body to the plasma concentration; it indicates distribution extent and tissue storage.
• D. The amount of drug excreted per hour.

Answer: (C)